Sunday, March 3, 2013

The Yeshiva World New Study Says Holocaust Infrastructure Was ...

aushnThe Holocaust ? the systematic, state-sponsored murder, persecution and abuse of millions ? was far more shocking and horrific than even experts thought a few months ago.

New research shows that about 42,500 Nazi camps and ghettos stretched from Nazi-controlled France to Russia between 1933 and 1945, Hitler?s vicious reign of terror and darkness.

The prevalence of camps in Germany, in particular, astonished researcher Martin Dean. Berlin, for instance, had about 3,000 camps and Hamburg had 1,300 sites.

?You literally could not go anywhere in Germany without running into forced labor camps, P.O.W. camps, concentration camps,? said Dean. ?They were everywhere.?

Dean and fellow scholar Geoffrey Megargee presented their findings at the German Historical Institute in Washington in late January, reported The New York Times.

Megargee expected to find about 7,000 camps and ghettos when research began. The final number of 42,500 locations sent shudders throughout the room.

?The numbers are so much higher than what we originally thought,? institute director Hartmut Berghoff told the newspaper. ?We knew before how horrible life in the camps and ghettos was ? but the numbers are unbelievable.?

The research team uncovered 30,000 slave camps, 1,150 Jewish ghettos, 1,000 prisoner-of-war camps, 980 concentration camps, 500 sex-slave brothels and thousands of other camps serving a myriad of wicked ends: forced abortions, mandatory euthanasia of the elderly and ill, ?Germanisation? and transportation hubs to murder sites, according to the Times.

The team started its research in 2000 for a seven-volume encyclopedia published by the Holocaust Museum, who have already released the first two volumes and expect to release all seven by 2025.

(Source: NY Daily News)

Source: http://www.theyeshivaworld.com/?p=159125

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Video: Santelli's Morning Bond Update

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Source: http://www.nbcnews.com/video/cnbc/51005952/

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Saturday, March 2, 2013 - Family Home and Life: Grandparent's Say ...

Good morning! Well the world seems all shiny ?and bright today....I'm not sick!! And no one is lost :) I am busier than a long tailed cat in a room full of rocking chairs and toddlers though. I thought life would be a lot slower during these years than it is. How about you, are you super busy or have you slowed down a bit?


It was a busy week with the grand kids too. My second oldest has wanted a hot air balloon ride since she was tiny and got her wish for her sixth birthday. She wasn't a bit afraid, but then after you have?flown as an angel?dangling from wires I guess a balloon ride isn't that different! That's Lake Pleasant there in the distance. Kc you would have loved it!?
It was Daddy daughter dance this last week. I am one proud mama/grandma of those two!Such a fun and affirming night for girls. Doesn't my grand daughter look like her daddy? ??

We have celebrated the last birthday (of what I call birthday season) for about 3 weeks before another birthday rolls around. That's about as long as we go without a birthday party around here. I actually stuffed money in a birthday card last week, a very rare thing for me to do because I always make something. But I am running out of time left and right. I need to clone myself or become twins....or have the energy Joyce has ;)?

This month I am celebrating my blog?anniversary?and I would like to have some guest posters from the grandma bloggers; anyone interested? It is last minute I know but if you would like to write a post, please send me an email.Thanks for stopping by today! Love you guys!


Button pic 9


This is a link up for older bloggers; but you don't need to be a grandparent to link up.?Link up to three post, not to your home page, and link that back to Family Home and Life. While you are here I hope you will visit the other linkers and come back to see who links up later. We all love comments! No Etsy shops or giveaways please. This link closes on Monday night.?

Be sure to visit Lisa at?Grandma's Briefs?to join her linky, GRAND Social, on Mondays. Thank you for linking up with me!





If you are reading this post anywhere else but at Family Home and Life then it was used without permission! Please report it! Copyright ? Family Home and Life 2010-2013 All Rights Reserved

Source: http://www.familyhomeandlife.com/2013/03/grandparents-say-it-saturday_2.html

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Saturday, March 2, 2013

America's happiest (and most miserable) states

According to a Gallup poll released Thursday, the United States has shown almost no improvement in well-being in the past five years, increasing slightly from 2011 when Americans reported the most miserable scores since the survey began.The top and bottom states have also remained nearly the same. West Virginia, which received the lowest well-being score in 2012, has routinely been in the bottom two, and Hawaii ranked highest for the fourth year in a row.

The Gallup-Healthways Well-Being Index, which has surveyed 1.7 million Americans since the survey was first conducted in 2008, reflects the physical and emotional health of residents in each of the 50 states. 24/7 Wall St. reviewed the scores of each state in the six categories that comprise Gallup?s index to identify objective measures that impact well-being.

Gallup Editor-in-Chief Frank Newport explained to 24/7 Wall St. that well-being is important because happier, healthier citizens tend to have positive social and economic impacts on the places they live.

?Well-being is important because of the hypothesis that it leads to good outcomes,? Newport said. ?If your citizens have high well-being, they?re more likely to be better citizens and engage in better behaviors and make things better all the way around. It?s a positive goal for those that look at what we ought to emphasize in society.?

Among the 55 questions Gallup asked residents in each of the past five years, there were certain categories that the states with low well-beingtended to do poorly in and high well-being states tended to do well in. States with high well-being had populations that smoked less, exercised more and tried to learn new things each day. These states also tended to share the outcomes of those behaviors and activities ? residents had lower levels of key health problems such as high blood pressure, diabetes and heart attacks, and had more energy.

Of the data 24/7 Wall St. considered in addition to Gallup?s indices, several showed a strong relationship with well-being. It appears that states with happy residents tended to have much lower poverty rates and higher median income. The states with the highest levels of well-being all have poverty levels below the national rate. Having stable income is important because it enables people to meet basic needs such as healthy food, clean water, medicine and health care.

We also found a strong relationship between employment and high school graduation rates and well-being. All 10 high well-being states had unemployment rates lower than the national average. All 10 states were in the top 15 for adults with a high school diploma.

In an interview with 24/7 Wall St., Gallup research head Dan Witters explained how these may be connected. Health and emotional well-being, he noted are more likely to be present in ?a more vibrant, more intellectually and psychologically attuned citizenry.? These people are more likely to be attractive to employers and to lead fulfilling lives. Witters added that healthier populations attract employers because they present less of a health care expense.

While many of the happiest and most miserable states have remained the same, many other states, Witters added, have seen significant improvement over time. In particular, seven states ? Colorado, Indiana, Nebraska, New York, Pennsylvania, Vermont and Wisconsin ? have shown statistically significant improvement. What?s more, these states all improved in the same few categories. These included obesity, smoking, access to basic needs and safety. ?I think there?s a good learning opportunity there for other states,? said Witters. ?If you look at those states that have moved the needle, they?ve gotten there through similar means.?

According to 24/7 Wall St.?s analysis, states in some areas of the country continue to do better than others. Of the 10 states with the highest levels of well-being, the majority are either in the West or Midwest. Of the 10 states with the lowest well-being scores, eight are located in the South. This has been the case since the survey began.

24/7 Wall St. reviewed all 50 U.S. states based on their scores in Gallup-Healthway?s 2012 Well-Being Index. On top of calculating an overall national level of well-being, the index also calculates the well-being for each state, assigning scores from 0 to 100, with 100 representing ideal well-being. The national score increased marginally in 2012, from 66.2 in 2011 to 66.7 in 2012. In generating the rank, Gallup combined six separate indices, measuring access to basic needs, healthy behavior, work environment, physical health, life evaluation and optimism, and emotional health. In addition to the index, we considered data from the U.S. Census Bureau, including income, poverty and the percentage of adults with a high school diploma or higher, all for 2011. From the Bureau of Labor Statistics, we reviewed state unemployment rates as of December 2012. We looked at life expectancy at birth, as of 2007, from the Kaiser Health foundation. We also considered violent crime rates for 2011 by state from the FBI Uniform Crime Report Program. All data are for the most recent period available.

Related: Looking for a bad time? Visit America's 'saddest,' 'most miserable' cities

Top five most happy states:

1. Hawaii

Well-being index score: 71.1

Life expectancy: 81.5 years (the highest)

Obesity: 25.7% (20th lowest)

Median household income: $61,821 (8th highest)

Adult population with high school diploma or higher: 90.6% (10th highest)

In Gallup?s 2012 well-being index, Hawaii performed better than any other state. It ranked first or second in five of the six categories that make up the index, and 14th in basic access to care. Hawaii?s residents reported being generally happier with their current lives than those of any other state. They were also a more optimistic group. More than two-thirds of Hawaiians reported not feeling stressed, compared to just 52.8 percent of West Virginians who could say that. A larger proportion of Hawaiians exercise than any state but Alaska, and residents also eat healthily and do not smoke. At the latest count, life expectancy at birth in the state was 81.5 years, by far the best in the country.

2. Colorado

Well-being index score: 69.7

Life expectancy: 79.9 years (9th highest)

Obesity: 18.7% (the lowest)

Median household income: $55,387 (15th highest)

Adult population with high school diploma or higher: 90.2% (15th highest)

Coloradans were among the most likely Americans to practice healthy behaviors, such as exercising regularly and eating fruits and vegetables. They were also among the least likely to smoke and among the most likely to report easy access to a safe place to exercise. Their healthy behavior appears to be paying off. Colorado was rated the best state for physical health in the United States, having some of the nation?s lowest rates of high blood pressure, high cholesterol, diabetes and obesity. Colorado residents were also among the nation?s healthiest emotionally, and they had high evaluations of their own lives.

3. Minnesota

Well-being index score: 68.9

Life expectancy: 80.9 years (2nd highest)

Obesity: 24.7% (13th lowest)

Median household income: $56,954 (11th highest)

Adult population with high school diploma or higher: 92.0% (2nd highest)

Gallup found that Minnesota had better emotional health than all but two states. Some 86 percent of Minnesotans reported they did not feel an excessive amount of sadness during the previous day, a higher percentage than all but one state. In addition, Minnesotans ranked third in the physical health category. Nearly 83 percent of survey respondents said they did not have health problems that prevented them from doing activities typical of their age group ? a higher-percentage than any other state. According to the most recent data, Minnesotans had the second-highest life expectancy of any state. Also, more than 78 percent of respondents said poor health did not get in the way of their usual daily activities, a higher percentage than all but one state.

4. Utah

Well-being index score: 68.8

Life expectancy: 80.1 years (8th highest)

Obesity: 23.9% (6th lowest)

Median household income: $55,869 (14th highest)

Adult population with high school diploma or higher: 90.3% (14th highest)

Utah residents had higher evaluations of their present lives and higher expectations for the future than residents of nearly every other state. More than 55 percent of respondents were thriving, while less than 3 percent were considered to be suffering based on their assessments of their present and future quality of life. In addition to strong evaluations of their own lives, Utah residents had better emotional health and a higher quality of their work environment than residents of most other states. Nearly 70 percent of respondents told Gallup they had recently learned something new or interesting, a higher percentage than any other state.

5. Vermont

Well-being index score: 68.6

Life expectancy: 79.7 years (12th highest)

Obesity: 25.7% (20th lowest)

Median household income: $52,776 (19th highest)

Adult population with high school diploma or higher: 91.8% (4th highest)

Vermont residents display healthier behaviors than any other state in the U.S. For example, nearly 72 percent of Vermont residents told Gallup that they ate healthily all day during the previous day, a higher percentage than any other state except Rhode Island. In fact, nearly two-thirds of respondents said they had at least at least five or more servings of fruits and vegetables in four of the past seven days, a higher proportion than any other state. Nearly 60 percent of residents said they exercised for at least 30 minutes in three of the past seven days, a higher percentage than all but two other states. The state had among the lowest poverty rates in the country, which may help explain why Vermont residents reported having good access to most basic needs. The state had the second-smallest proportion of residents say they did not have enough money to feed their families.

The five most miserable states:

1. West Virginia

Well-being index score: 61.3

Life expectancy: 75.2 years (2nd lowest)

Obesity: 33.5% (the highest)

Median household income: $38,482 (2nd lowest)

Adult population with high school diploma or higher: 84.2% (12th lowest)

West Virginia residents? well-being was the worst of all states. It scored dead last in three of the six categories: life evaluation, emotional health and physical health. The answers of West Virginians to questions in the physical health category were particularly alarming. It was the only state where more than 30 percent of residents were told by a physician or nurse that they had high cholesterol. In addition, nearly 40 percent of respondents were told they have high blood pressure, also the highest of all states. Unhealthy behaviors could be causing these problems. For instance, just 62.2 percent of West Virginians indicated they ate healthily the previous day, the fifth-lowest percentage of all states. Moreover, 31.4 percent of respondents indicated that they smoked, the highest percentage of all states. The state had the second-lowest median income in the U.S., and a very high proportion of those surveyed in the state reported not being able to afford food or medicine. West Virginians had the second-worst life expectancy at birth in the country.

2. Kentucky

Well-being index score: 62.7

Life expectancy: 76.2 years (7th lowest)

Obesity: 29.7% (6th highest)

Median household income: $41,141 (4th lowest)

Adult population with high school diploma or higher: 83.1% (6th lowest)

The state has one of the lowest proportions of adults with a high school degree, as well as the fourth-lowest median income in the country. Kentucky also ranked dead-last in terms of healthy behaviors. A mere 60.7 percent of respondents said they ate healthily the day before, by far the lowest of any state. Not surprisingly, Kentucky also ranked second from the bottom in terms of physical health. As many as 29 percent of people indicated they had health problems that prevented them from doing age-appropriate activities, a higher percentage than any state other than West Virginia. Kentucky also ranked second from the bottom in the life evaluation and emotional health categories.

3. Mississippi

Well-being index score: 63.6

Life expectancy: 74.8 years (the lowest)

Obesity: 32.2% (2nd highest)

Median household income: $36,919 (the lowest)

Adult population with high school diploma or higher: 81.1% (3rd lowest)

Mississippi ranked lower than any other state in Gallup?s basic access to necessities category. For instance, nearly 25 percent of state residents indicated they did not have enough money to buy food for themselves or their family at some point in the last 12 months, the highest percentage of all states. Such problems are likely due to the state?s high-poverty rate and overall low incomes. The state?s median household income of $36,919 was the lowest of all 50 states, and the poverty rate of 22.6 percent was the highest. The lack of basic access to necessities may partly help explain why Mississippi ranked sixth from the bottom in terms of physical health. More than 38 percent of residents indicated they were told by a doctor or nurse that they had high blood pressure, a higher percentage than any state except for West Virginia. In addition, 15.4 percent of residents were told they had diabetes, more than any other state.

4. Tennessee

Well-being index score: 64.0

Life expectancy: 76.2 years (8th lowest)

Obesity: 29.6% (7th highest)

Median household income: $41,693 (6th lowest)

Adult population with high school diploma or higher: 84.2% (12th lowest)

According to the FBI, Tennessee had the nation?s highest violent crime rate in 2011, at over 608.2 violent crimes per 100,000 residents. This likely affected the state?s rank in Gallup?s access to basic necessities category, which included a question about being able to walk alone at night safely. The state ranked 11th worst in the U.S. in that question. In addition, Tennesseans reported some of the most critical conditions when it came to their own working environments. They were also among the Americans most likely to report they had poor health behaviors, such as not eating well. Just less than 62 percent of Tennesseans indicated they ate healthily all day the day prior to being surveyed?worse than every state but Kentucky. Such unhealthy behavior potentially contributed to the state?s low scores for both emotional and physical health. Residents were among the nation?s most likely to reveal they felt sad or depressed, and also among the most likely to have high blood pressure or cholesterol.

5. Arkansas

Well-being index score: 64.1

Life expectancy: 76.1 years (6th lowest)

Obesity: 31.4% (3rd highest)

Median household income: $38,758 (3rd lowest)

Adult population with high school diploma or higher: 83.8% (8th lowest)

Arkansas ranked in the bottom 10 in all but one of the well-being categories. The state ranked fourth from the bottom in terms of physical health. A higher percentage of people were told they had cancer compared to any other state. More than 31 percent of respondents were clinically obese, a higher percentage than all but two states. Arkansas also ranked fourth from the bottom in healthy behaviors. Over 27 percent of the population indicated that they smoked, the fourth-highest rate of all states. The average life expectancy in the state was just over 76 years old, the sixth-lowest of all states. Good health could be impeded by the state?s low income. The state?s median household income of $38,758 in 2011 was the third lowest of all states.

See where your state ranks on the complete list.

?2013 24/7 Wall St.

Source: http://www.nbcnews.com/business/americas-happiest-most-miserable-states-1C8627202

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Boeing touts a 'permanent' fix for 787 Dreamliner batteries, Japan stays cautious

Boeing says it has a 'permanent' fix for 787 Dreamliner batteries, Japan remains cautious

There's been talk for weeks of Boeing developing a fix for the 787 Dreamliner's battery fire troubles. If the aircraft maker has its way, that should soon translate to action. The company's commercial airplane chief, Raymond Conner, tells reporters that the company has a "permanent" fix that would place three layers of protection around the batteries and, theoretically, head off fires and their causes. It sounds like just the ticket -- the challenge will be getting everyone else to feel the same way. American investigators believe the batteries are at fault, but their Japanese counterparts haven't yet ruled out external factors. With this kind of ongoing debate, we're not about to book a 787 to Tokyo for spring break.

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Source: New York Times

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/QySBhJPYPJQ/

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Friday, March 1, 2013

TMN Go launches on iOS and the web, brings HBO Go-style ...

Ready, Set, The Movie Network GO! - New Video Streaming Service Gives Subscribers Access to The Movie Network, HBO Canada and TMN Encore from their iPhone, iPad, iPod touch, Mac or PC Whenever, Wherever
TORONTO, Feb. 27, 2013 /CNW Telbec/ - Astral's The Movie Network today announced the launch of The Movie Network GO (TMN GO), HBO GO Canada and TMN Encore GO, three new video streaming services that put more than 1,500 hours of high-definition quality programming from The Movie Network, HBO Canada and The Movie Network Encore (TMN Encore) at subscribers' fingertips. Available at no additional cost with a subscription to The Movie Network and TMN Encore, TMN GO offers instant and unlimited access to more than 1,200 titles comprised of Hollywood hit movies, exclusive series from HBO, CINEMAX and Showtime, and classics from every era. With the launch of TMN GO, subscribers can now watch what they want, when they want, where they want from their iPhone, iPad, iPod touch, Mac or PC. TMN GO is currently available in Eastern Canada to customers of Bell Fibe TV, Bell Satellite TV and Cogeco Cable, with Rogers launching the service in the coming weeks and additional television providers expected to join shortly thereafter.

"TMN GO with HBO GO Canada and TMN Encore GO are extensions of Astral's commitment to providing Canadians with unparalleled premium content across multiple platforms," said Domenic Vivolo, Senior Vice President, Sales and Marketing, Astral Television Networks. "TMN was the first movie service in Canada to offer a dedicated HD channel with TMN HD, the first in Canada to launch an SVOD service with TMN OnDemand, and the first in North America to offer subscribers an authenticated broadband streaming service with TMN OnLine. TMN GO is the latest such innovation from Astral and TMN and we believe it will be a game changer for our business - providing subscribers with a value and entertainment proposition that represents the ultimate in choice, control and convenience."

With a sleek cinematic design and interface that offers superior functionality, TMN GO, HBO GO Canada and TMN Encore GO are best-in-class services that allow subscribers to engage with over 1,200 titles and 1,500 hours of premium content. TMN GO, HBO GO Canada and TMN Encore GO can all be accessed at www.tmngo.ca or by downloading the TMN GO App from the App Store. Key features of the service include:

Pick-up-and-play technology which allows users to start watching on one device and continue on another;
The Watchlist function which lets users keep up with their favourite series throughout the run. Once a series is added to the Watchlist, new episodes are automatically added and the user is notified when they are available. Upcoming movie titles can also be tracked and added to the Watchlist, with reminder notices when the title is available;
Parental controls which allow users to manage the content that family members of every age have access to;
Social networking functionality that enables users to share and like favourite titles instantly with friends over Facebook, Twitter and email;
Multiple members of the household can enjoy the service with up to three simultaneous streams and five registered devices per subscriber household, each with their own Watchlist;
The ability to stream over WiFi and 3G (or above) networks, allowing users to manage their data consumption;
Adaptive streaming which automatically switches video quality to ensure the best viewing experience available based on the user's Internet connection.
Video quality control which gives users control over video quality, allowing them to further control their bandwidth consumption.
TMN GO's selection mirrors the programming offering from The Movie Network OnDemand, HBO Canada OnDemand and TMN Encore OnDemand, with new content refreshed weekly. TMN GO will also be home to new, never-before-seen bonus material and content such as an exclusive collection of four short digital HBO comedies - The Boring Life of Jacqueline, Brody Stevens: Enjoy It!, Garfunkel and Oates, and Single Long - from the likes of Zach Galifianakis and Mike White.

At the time of launch, programming available on TMN GO includes hit series, movies, sports programming and documentaries from HBO including full seasons and current episodes of Game of Thrones, Girls, True Blood, Boardwalk Empire, Eastbound & Down, Enlightened, The Newsroom, Real Time with Bill Maher, Treme and VEEP; all seasons and episodes of HBO's genre-defining Band of Brothers, The Sopranos and The Wire; HBO films and documentaries such as Beyonc?: Life is But A Dream, In Vogue: The Editor's Eye, Game Change and The Girl; CINEMAX series such as Banshee and Hunted; acclaimed Showtime series such as Californication, Dexter, House of Lies, Oliver Stone's Untold History of the United States, Nurse Jackie and Shameless; hit Starz series Spartacus: Vengeance and Spartacus: War of the Damned; Hollywood hit movies and family favourites such as The Artist, Battleship, Conan The Barbarian, Dolphin Tale, Drive, Fast Five, The Five Year Engagement, Goon, Happy Feet Two, Harry Potter and the Deathly Hallows Part 2, The Ides of March, The Lucky One, Moneyball, Mirror, Mirror, The Muppets, Snow White and The Huntsman, That's My Boy, The Vow, Wanderlust and War Horse; acclaimed, award-winning Canadian series and movies like Barney's Version, Call Me Fitz, The Captains, The Crimson Petal & The White, Funny As Hell, Good God, Goon, Less Than Kind, Monsieur Lazhar, Starbuck, Transporter: The Series, The Whistleblower, and many more; and hundreds of classic movies from every era and genre offered by The Movie Network Encore such as Bad Boys, The English Patient, Jaws, Life Is Beautiful, Out of Sight, The Sting, To Kill a Mockingbird, True Romance and many more.

TMN GO is supported by the iPhone 3GS and subsequent models, iPod touch (3rd and 4th generation) and the iPad and iPad Mini (running iOS 5.0 or higher).

The TMN GO App is available for free from the App Store on iPhone, iPad and iPod touch or at www.AppStore.com/TMNGO.

The Movie Network is a pay television service available in eastern Canada. With premiere access to Hollywood hit movies, new and exclusive HBO content, critically acclaimed Showtime series and first-rate Canadian programming, this pay-television service presents Canadians with some of the best television entertainment available. The Movie Network service includes five 24-hour multiplex channels - The Movie Network, HBO Canada, MExcess, MFun! and MFest - which deliver diverse and entertaining programs in an uncut and commercial-free television environment. All five multiplex channels are also simulcast in High Definition and are joined by The Movie Network OnDemand, a Subscription Video On Demand (SVOD) service, available in select areas across eastern Canada; TMN OnLine an Internet-based content streaming service available to BellTV, Rogers and Videotron subscribers; and TMN GO, a video streaming service currently available to Bell TV and Cogeco Cable subscribers. For more information, please visit www.themovienetwork.ca.

TMN GO and The Movie Network are members of the Astral family. Astral Media Inc. (TSX:ACM.A/ACM.B) is one of Canada's largest media companies. It operates several of the country's most popular pay and specialty television, radio, out-of-home advertising and interactive media properties. Astral plays a central role in community life across the country by offering diverse, rich and vibrant programming that meets the tastes and needs of consumers and advertisers. To learn more about Astral, visit astral.com.

SOURCE: THE MOVIE NETWORK

Source: http://www.engadget.com/2013/03/01/tmn-go-launches-on-ios-and-the-web-brings-hbo-go-style-experien/

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'Wrong' immune response aids TB

Some bacteria, including tuberculosis, are able to invade because the body launches the 'wrong' immune response, say researchers.

Instead of fighting off tuberculosis, people with a severe infection produce a protein which attacks viruses, the journal Science reports.

About 8.7 million people are infected with tuberculosis every year.

The findings may explain why viruses can make people more susceptible to bacterial infections.

A spring peak in tuberculosis infections may be linked to the effects of viruses circulating in winter, experts suggested.

US researchers first identified the phenomenon using leprosy - which is caused by a similar bacterium to tuberculosis.

Looking at skin lesions in leprosy patients, the team found that two different immune proteins were present.

In those with a milder form of the disease, they found a protein associated with a bacterial immune response - interferon-gamma.

Whereas in patients with a more serious form of leprosy, a protein associated with a viral response - interferon-beta - was prominent.

Further work showed the genes for interferon-beta - the virus-fighting protein - were more frequently expressed in the blood of tuberculosis patients with more severe disease.

In disguise

The researchers said in those with severe disease, the body was responding as if it was attacking a virus, enabling the bacteria to remain hidden and replicate unchallenged within cells.

Not only is interferon-beta an ineffective weapon against bacteria, it can block the action of interferon gamma - which is when bacteria can gain a foothold, the researchers said.

In the face of a real viral infection it may mean that the attention of the immune system is diverted letting a bacterial infection in.

Prof Robert Modlin, a dermatology and microbiology expert at the University of California, Los Angeles, said the study raises the possibility that a decrease or increase of one of these two proteins could shift the balance from mild to more serious disease.

"We may find that therapeutic interventions to block or enhance specific interferon responses may be an effective strategy to alter the balance in favour of protection against bacterial diseases."

The results may also help to explain why outbreaks of tuberculosis in winter such as one currently spreading among homeless groups in Los Angeles are quick to take hold.

A potent combination of people sleeping in close quarters in shelters, flu outbreaks diverting the body's immune response to the viral setting and a lack of vitamin D from sunlight, which also impacts the immune response, may be to blame, they suggested.

"With TB on the rise, this scenario could play out not only in cities in the United States but all over the world," Prof Modlin said.

Prof Ajit Lalvani, director of the Tuberculosis Research Unit at Imperial College London said there is a spring peak in rates of tuberculosis which have been attributed to low levels of vitamin D.

"But this shows there could be at least one other reason - that other viral infections are leading some months down the line to progression from latent to active TB disease.

"The timing fits, but that remains to be proven."

Source: http://www.bbc.co.uk/news/health-21619594#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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