Friday, November 30, 2012

mesothelioma mancini: Web Cam Modeling - samuelfolkes.com ...

Image of Web Cam ModelingAs a webcam model, offering a customer service. And before the process, you must be well aware of the brand of your computer model, operating system, more camera models from Logitech. In general, there are two types, models webcam webcam amateur and professional models. You as a webcam model solo or couple webcam modeling must be willing to work overtime if you want to be successful in business and earn more. You might even consider having a professional photo taken, because it can give you a huge competitive advantage with webcam models. Here's how to get started on your way to earn a six figure income as a webcam model.
Contrary to what you may have heard, you do not need to look like a model air brushed to earn dollars superiors as a webcam model. Step 3: Set Your Price Choose a site webcam that allows your game your own cost per minute. To become a webcam model, in general, you will need to have reached the legal age for the country you're living it, you will be asked to present some kind of proof of age in the context of the USC Webcam Modeling is one of the highest paying jobs online is becoming increasingly popular as the Internet continues to grow. If you are not making as much money as you want, you have some things that you can try so you will be able to earn more on your webcam jobs. Once you've been hired by a modeling company and internet after obtaining essential as a webcam and broadband Internet access, you will need to learn how to become a top performer.
If you can meet the needs of your customers, you can be sure that you will look for the next time he is online. This will ensure that you work and manage your own online business from home legally. Professional webcam models are not for everyone, it is a very competitive field, but if you have what it takes then it is one of the safest and easiest way to make money online , not to mention the flexibility of the job. Tip # 1 ? Boost your online profile Many people who are looking for a couple of modeling or just a webcam model webcam chat online course will start looking at profiles online webcam models to see which one you. If you're like me, you've read about many ways to make money online with a website or a blog. Internet and Businesses Online: Audio-Streaming
If you are a stay at home mom looking for a way to earn money without having to leave the house, then becoming a webcam model may be the good job for you. If you work as a model of webcam you can make lots of money as long as you know what you are doing. This is how you build a fan club rehearsal paying members so that you spend more time online to earn money in private show. Give them a reason to stay in your room and you pay tons of money. Obviously, the more hours you work, the more money you will make. It is by no means mandatory and you can always make money register for freebie sites or other methods mentioned above.
Sometimes, your visitor will even pay for private chat just to spend time with you alone. You will also want to make sure you put in enough time to start seeing a difference. Invest time in the development of quality, well placed lighting so that you look your best on camera. Manually get the right driver Logitech Web Camera is a difficult chore and time consuming. A broadcast network that has the greatest number does not always mean that you will make more money by working with them, this type of network usually have over 1000 models online at any time if you have to compete with them while you post. Webcam modeling is a scam free, safe and profitable to make hundreds, even thousands of dollars each week working in your free time in a relatively comfortable.
Assessments bought their house a little work for us and pay for everything they want cash only! In the current labor market difficult, there are no other jobs you can do at home that will earn you as much money and allow you the greatest flexibility webcam fun. Tip # 2 ? Consider your appearance as a webcam model you can work from home, but consider the nature of your business. Studio work is an alternative, and it brings the benefits of diffusion in high quality videos which a typical set up simply can not compete. Being a webcam model is one of the few jobs where you can make great money from the comfort of your own home while having fun. With a little motivation, hard work and commitment to put in the time required, you can be making $ 500 per week (sometimes more) as a webcam model new working 20-25 hours per week Home.

Source: http://www.samuelfolkes.com/web-cam-modeling/

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New Zealand declare, set Sri Lanka 363 ? Cricket News Roundup ...

New Zealand declare, set Sri Lanka 363 ? Cricket News Roundup ? Part 2 ? November 28, 2012

New Zealand have set Sri Lanka a target of 363 after declaring their second innings on 194 for 9, with skipper Ross Taylor leading the way with another half-century.

The Lankans began the day on 225 for 6 but managed to add just 19 more runs. The major damage was done by Trent Boult, who dismissed the overnight pairing of Thilan Samaraweera and Suraj Randiv in back to back overs before taking the final wicket of Rangana Herath. Tim Southee also got a scalp to finish with a five-wicket haul.

New Zealand were restricted to 75 for 5 before Todd Astle and Taylor rescued the innings with a 97-run stand for the sixth-wicket. Astle?s wicket sparked a late order collapse before the Kiwis eventually decided to declare. ?

Australian pacer, Peter Siddle, is confident of overcoming fatigue and feature in the deciding Test against South Africa, which starts on Friday at Perth.

Following an injury to fellow seamer James Pattinson, Siddle was forced to share the bulk of the bowling workload and sent more than 60 overs during the drawn Test at Adelaide. He is now a doubt for the final clash with the selectors already bringing in reinforcements in the shape of Mitchell Johnson, John Hastings and Josh Hazlewood.

Siddle, who will not bowl before the start of the Test, said that he can still make it to the playing XI. "I'm feeling good now, I've recovered well ... but if I'm struggling through tomorrow or if I don't feel 100 percent I've got to talk to the captain, the selectors and work out what's best."

Melbourne Renegades have scooped up South African batsman, Faf Du Plessis, for their Big Bash season?s opener against rivals Melbourne Stars.

Du Plessis, who scored a heroic ton against Australia at Adelaide, will take the place of West Indian Marlon Samuels, who is unavailable for the derby clash due to his commitments with the national side.

He becomes the second current Proteas player to a pen a short term deal after Dale Steyn opted to join Brisbane Heat for their opening clash against Sydney Thunder.

"Faf's one of the best fielders in world cricket and an explosive T20 batsman," Renegades coach, Simon Helmot said. "His batting and fielding are what we needed and he can bowl some handy leg-spin as well."

Source: http://blogs.bettor.com/New-Zealand-declare,-set-Sri-Lanka-363-Cricket-News-Roundup-Part-2-November-28,-2012-a204175

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Thursday, November 29, 2012

New method of manufacturing smallest structures in electronics: Discovery could revolutionize semiconductors

ScienceDaily (Nov. 28, 2012) ? A completely new method of manufacturing the smallest structures in electronics could make their manufacture thousands of times quicker, allowing for cheaper semiconductors. The findings have been published in the latest issue of Nature.

Instead of starting from a silicon wafer or other substrate, as is usual today, researchers have made it possible for the structures to grow from freely suspended nanoparticles of gold in a flowing gas.

Behind the discovery is Lars Samuelson, Professor of Semiconductor Physics at Lund University, Sweden, and head of the University's Nanometre Structure Consortium. He believes the technology will be ready for commercialisation in two to four years' time. A prototype for solar cells is expected to be completed in two years.

"When I first suggested the idea of getting rid of the substrate, people around me said 'you're out of your mind, Lars; that would never work'. When we tested the principle in one of our converted ovens at 400?C, the results were better than we could have dreamt of," he says.

"The basic idea was to let nanoparticles of gold serve as a substrate from which the semiconductors grow. This means that the accepted concepts really were turned upside down!"

Since then, the technology has been refined, patents have been obtained and further studies have been conducted. In the article in Nature, the researchers show how the growth can be controlled using temperature, time and the size of the gold nanoparticles.

Recently, they have also built a prototype machine with a specially built oven. Using a series of ovens, the researchers expect to be able to 'bake' the nanowires, as the structures are called, and thereby develop multiple variants, such as p-n diodes. A further advantage of the technology is avoiding the cost of expensive semiconductor wafers.

"In addition, the process is not only extremely quick, it is also continuous. Traditional manufacture of substrates is batch-based and is therefore much more time-consuming," adds Lars Samuelson.

At the moment, the researchers are working to develop a good method to capture the nanowires and make them self-assemble in an ordered manner on a specific surface. This could be glass, steel or another material suited to the purpose. The reason why no one has tested this method before, in the view of Professor Samuelson, is that today's method is so basic and obvious. Such things tend to be difficult to question.

However, the Lund researchers have a head start thanks to their parallel research based on an innovative method in the manufacture of nanowires on semiconductor wafers, known as epitaxy -- consequently, the researchers have chosen to call the new method aerotaxy. Instead of sculpting structures out of silicon or another semiconductor material, the structures are instead allowed to develop, atomic layer by atomic layer, through controlled self-organisation.

The structures are referred to as nanowires or nanorods. The breakthrough for these semiconductor structures came in 2002 and research on them is primarily carried out at Lund, Berkeley and Harvard universities.

The Lund researchers specialise in developing the physical and electrical properties of the wires, which helps create better and more energy-saving solar cells, LEDs, batteries and other electrical equipment that is now an integrated part of our lives.

Besides Lars Samuelson, the other authors of the article are: Magnus Heurlin, Martin Magnusson, David Lindgren, Martin Ek, Reine Wallenberg and Knut Deppert, all employed at Lund University, except for Martin Magnusson, who works at start-up company Sol Voltaics AB.

About semiconductors Semiconductors are materials that neither conduct electricity as well as metals, nor stop a current as effectively as insulators -- silicon and germanium are two examples. These properties may not sound attractive, but in actual fact they are excellent. The reason is that we can influence the conductive capacity of the materials, for example by introducing impurity atoms, known as doping. Materials with different types of doping can be combined to manufacture products such as transistors, solar cells or LEDs.

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The above story is reprinted from materials provided by Lund University.

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Journal Reference:

  1. Magnus Heurlin, Martin H. Magnusson, David Lindgren, Martin Ek, L. Reine Wallenberg, Knut Deppert, Lars Samuelson. Continuous gas-phase synthesis of nanowires with tunable properties. Nature, 2012; DOI: 10.1038/nature11652

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/_Sy3gopuJIw/121128143942.htm

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How New York Will Stop the Subway From Flooding in the Next Huge Storm

New York knew for a long time that a big storm could flood and collapse the subway system, which is exactly what happened with Sandy. Yet city officials did nothing about it. But now, after all the suffering, we'll finally be prepared. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/nQsieEsVps4/how-new-york-will-stop-the-subway-flooding-in-the-next-huge-storm

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Wednesday, November 28, 2012

Remains of the Day: You Can Finally Merge Your Skype and Microsoft Accounts on iOS

Remains of the Day: You Can Finally Merge Your Skype and Microsoft Accounts on iOSSkype's iOS app finally gets Microsoft account integration, you can now preorder books from the Google Play store, Vimeo launches a redesigned iOS app, and Microsoft finally divulges details on the latest Windows Phone 7 update.

  • Skype 4.2 for iOS Released In keeping with its desktop updates, the lastet Skype for iOS update supports Microsoft account merging, in addition to in-app account creation. Also new are a tap and hold feature for editing IMs and the ability to edit saved numbers right from the dial pad. [App Store]
  • Preorder e-books from Google Play You can now preorder books from the Google Play store. Much like preordering on another service like Amazon, you'll need to have your payment information ready, although you won't be charged until your order actually ships. [CNET]
  • The New, New Vimeo App for iPhone Vimeo has relaunched their iOS app. The update comes with a new tab-based design, a new feed view, native Twitter and Facebook sharing, and background uploads so you can watch other videos while uploading your own. [Vimeo Blog]
  • An Update on Windows Phone 7.8 Windows Phone 7 will finally get it's long awaited 7.8 update in early 2013. 7.8 will give Windows Phone 7 users the Windows Phone 8 Start screen, more customization options and an improved lock screen. [Windows Blog]
  • Windows Blue is Microsoft's Future Low-Cost OS with Yearly Updates Rumors say that Microsoft is planning to shift to a yearly update schedule for it's OS releases, similar to Apple. The next Windows OS, codenamed Windows Blue, would release in mid-2013 and will release at a low cost?possibly free?and will work across Windows and Windows Phone. Upon release, it's possible that Blue will retain the Windows 8 name and run the same apps, but with Microsoft no longer accepting apps made exclusively for Windows 8. [The Verge]

Photo by photastic (Shutterstock), a2bb5s (Shutterstock), and Feng Yu (Shutterstock).

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/Xk4cYj_eIrg/remains-of-the-day-you-can-finally-merge-your-skype-and-microsoft-accounts-on-ios

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Video: PFT Live: Kaepernick getting nod over Smith?

Sorry, Readability was unable to parse this page for content.

Source: http://nbcsports.msnbc.com/id/21134540/vp/49982203#49982203

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LA Auto Show: 2013 Hyundai Santa Fe

This summer, Hyundai released the shorter wheelbase Santa Fe Sport, and now they have more details on its longer (by 8 inches) three-row sibling, the Santa Fe. Introduced during a pained, cheesy skit that incorporated a game show and a family dancing to Lenny Kravitz's "Are You Gonna Go My Way" (hey, if we have to sit through it, you have to read it), the 7-passenger Santa Fe will offer seating for 7 adults, more second row legroom, multiple second-row configurations, and more cargo space. It will also see a power lift gate and have an option for second-row captain chairs. Like the Sport, the Santa Fe will have a 12-speaker Harman Kardon audio system, panoramic sunroof, and side window shades. The standard engine will be a 3.3-liter V-6 that will put out 270 hp and 252 lb. ft. of torque.

Source: http://www.popularmechanics.com/cars/news/auto-blog/la-auto-show-2013-hyundai-santa-fe-14793274?src=rss

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Gender pay gap is eroding, especially among younger women, US data show

Women are slowly making inroads in the gender pay gap. Recent Bureau of Labor Statistics data for full-time workers show women earn 82 percent as much as men, up from 64 percent in 1980.

By Amanda Paulson,?Staff writer / November 27, 2012

Vanessa Ma'et, front, an employee with Gallup, works at one of their call centers making phone calls doing polling for various organizations, on June 7, 2012 in Omaha, Nebraska. New data show that the gender pay gap is narrowing.

Melanie Stetson Freeman/The Christian Science Monitor

Enlarge

Women are, slowly, making inroads in the gender pay gap ? an issue that got some attention in the presidential campaign this fall, as President Obama touted his signing of the Lily Ledbetter Fair Pay Act, and both candidates answered a question on the topic in the town hall debate.

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According to the latest numbers released by the Bureau of Labor Statistics (BLS) last week, based on the weekly earnings of full-time wage and salary workers, women now earn 82 percent as much as men ? up from 64 percent in 1980.

In recent discussions of the wage gap, a different figure ? 77 percent ? has been widely cited. That figure it also accurate, but the measure, which comes out in the spring, looks at median annual earnings for full-time year-round workers; it includes self-employed workers, which the weekly numbers exclude, and excludes seasonal workers. The figures are based on the same raw BLS data.

Most notably, in the BLS numbers released the day after Thanksgiving, the earnings of women between the ages of 25 and 34 have shot up fairly substantially over the past 32 years, from 69 percent of men's earnings in 1980 to 92 percent in 2011.

The gap still widens, though, as women age ? a sign that while many young women enter the workforce on a more equal playing field with their male counterparts, they still tend to fall behind on income as they age.

"A tremendous amount of progress has been made [on the earnings gap between men and women], in many ways more than I thought would be made," says Heidi Hartmann, president of the Institute for Women's Policy Research in Washington. The wage gap, she notes, has been cut nearly in half. "It's not good enough, but it's progress," Ms. Hartmann says.

And progress has also been made on the sex segregation of the labor market, with many previously male-dominated fields ? including law, banking, medicine, and civil service jobs like bus drivers and mail carriers ? opening up to women.

Both those trends are largely the result of women's increased entry into higher education, where female graduates have outnumbered male graduates since the mid 1980s.?

But Hartmann and others also caution that there's still a tremendous amount of work to do before women have true equality in the workforce.

A recent study from Catalyst, a nonprofit New York-based organization that promotes women in the business world, found that women in the business world are offered fewer of the "hot jobs" ? those jobs with high visibility, central to an organization's mission, that tend to lead to promotions down the road.

The Catalyst survey of top MBA grads found that men led projects with budgets more than twice the size of women's, with teams that were more than three times as large, and that posed a higher risk to the company. Men also had roles with significantly more critical responsibility ? one reason, Catalyst suggests in its analysis, for the persistent gender gap at senior levels that exists in the business world.

Another major factor in continuing inequities is the lack of parental supports, says Hartmann.

The US is one of the only countries in the world, she notes, without any guaranteed paid maternity leave ? and the only industrialized nation (the others include Lesotho, Papua New Guinea, and Swaziland).

And without the subsidized childcare costs that many nations have, many mothers have to factor child-care costs in their decision whether to return to work, and often take a leave of absence ? which they're later often penalized for when they do return to work.

And in a labor market where about half of US workers get no paid sick time at all, women are still most often the ones to skip work ? and forgo pay ? to stay home with sick children or other family members.

Still, women are slowly chipping away at the wage gap. And while paid parental leave remains elusive for many US workers, women have won a number of legal gains in the past 35 years that have helped contribute ? most notably the Pregnancy Discrimination Act of 1978 and the Family and Medical Leave Act of 1993 (which requires most employers to provide unpaid, job-protected leave of up to 12 weeks for family or medical reasons).

Some smaller employers are exempt from even these basic protections, notes Hartmann, "but the fact that we have them is better than [nothing]."

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/NweP4hISqQM/Gender-pay-gap-is-eroding-especially-among-younger-women-US-data-show

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Tuesday, November 27, 2012

Lenovo IdeaPhone P770 stuffs 29-hour battery and Jelly Bean into a lower-cost smartphone

Lenovo IdeaPhone P770 stuffs 29hour battery and Jelly Bean into a lowercost smartphone

Motorola may face a new contender to the Droid RAZR MAXX HD's battery capacity crown. Lenovo's quietly introduced IdeaPhone P770 at least theoretically challenges its American counterpart by cramming a 3,500mAh lithium polymer battery into a thicker 11.9mm (0.47-inch) body. That's 200mAh more than Motorola's energy champion, and enough for the company to flaunt a 29-hour talk time. That's not quite as long as Motorola's claimed 32 hours, but Lenovo has done something its American rival seemingly can't -- launch a phone with Jelly Bean. Motorola might rest easier in knowing that the the P770 is an unrepentantly budget-focused behemoth, carrying a 4.5-inch qHD display, a (possibly MediaTek-made) 1.2GHz dual-core processor, 4GB of built-in storage, an 8GB microSD card and both 5-megapixel rear as well as VGA front cameras. For the ¥1,699 ($273) Lenovo is asking for an off-contract model in its native China, the P770 could still be the first pick of many local phone owners on long-haul trips. It's just a shame that the lack of 4G (and Lenovo's domestic-first mobile strategy) likely means we won't see a launch in the US.

[Thanks, FT]

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/kND8vawzAvo/

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Carbon Monoxide Poisoning Hazards Rise in Colder Weather ...

Carbon Monoxide Poisoning Hazards Rise in Colder Weather

Heating devices such as fireplaces, furnaces, lanterns can emit deadly gas

SUNDAY, Nov. 25 (HealthDay News) ? The arrival of cold weather increases the risk of carbon monoxide poisoning, which can occur when gas furnaces, fireplaces and other heating devices don?t work properly and release the dangerous gas into homes, experts warn.

?You can?t see or smell carbon monoxide, but it can cause significant health issues and possibly kill you,? Dr. Kalpalatha Guntupalli, chief of the pulmonary critical care and sleep section at Harris Health Ben Taub Hospital and a professor at Baylor College of Medicine, said in a Harris Health System news release.

Carbon monoxide enters the bloodstream and robs the body of oxygen. Mild exposure to the gas can be easily treated, but high or prolonged exposure to carbon monoxide can be fatal.

Signs of carbon monoxide exposure include headache, dizziness, confusion, nausea or vomiting, and weakness.

Each year in the United States, about 400 people die and 4,000 are hospitalized for carbon monoxide poisoning, according to the U.S. Centers for Disease Control and Prevention. About 20,000 people get sick enough from carbon monoxide exposure to visit an emergency department.

The elderly, children and people with chronic conditions such as heart disease, anemia and lung problems are at greatest risk, the study authors noted.

Guntupalli?s team urged everyone to get their gas heating devices checked for carbon monoxide leaks. Other potential sources of carbon monoxide include gas stoves, lanterns and wood-burning fireplaces.

In addition, Dr. Nick Hanania, director of the Asthma Clinical Research Center at Harris Health Ben Taub Hospital and an associate professor at Baylor College of Medicine, pointed out that people should never use gas-powered generators or charcoal grills indoors, or use gas stove tops and ovens to stay warm.

All homes should have carbon monoxide detectors, he added.

?You could be creating carbon monoxide and not realize it until it?s too late,? Hanania said. ?The dangers of carbon monoxide are too great to ignore.?

More information

The American College of Emergency Physicians has more about carbon monoxide.

Related topics: Care Giving | Environmental | Gastrointestinal Problems | General Health | Head & Neck | Mental Health | Public Health | Respiratory Health

Source: http://www.thehealthcast.com/care-giving/carbon-monoxide-poisoning-hazards-rise-in-colder-weather/

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Metabolic protein launches sugar feast that nurtures brain tumors

ScienceDaily (Nov. 26, 2012) ? Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which brain tumors thrive.

They also found a vital spot along the protein's journey that can be attacked with a type of drug not yet deployed against glioblastoma multiforme, the most common and lethal form of brain cancer. Published online by Nature Cell Biology, the paper further illuminates the importance of pyruvate kinase M2 (PKM2) in cancer development and progression.

"PKM2 is very active during infancy, when you want rapid cell growth, and eventually it turns off. Tumor cells turn PKM2 back on -- it's overexpressed in many types of cancer," said Zhimin Lu, M.D., Ph.D., the paper's senior author and an associate professor in MD Anderson's Department of Neuro-Oncology.

Lu and colleagues showed earlier this year that PKM2 in the nucleus also activates a variety of genes involved in cell division. The latest paper shows how it triggers aerobic glycolysis, processing glucose into energy, also known as the Warburg effect, upon which many types of solid tumors rely to survive and grow.

"PKM2 must get to the nucleus to activate genes involved in cell proliferation and the Warburg effect," Lu said. "If we can keep it out of the nucleus, we can block both of those cancer-promoting pathways. PKM2 could be an Achilles' heel for cancer."

By pinpointing the complicated steps necessary for PKM2 to penetrate the nucleus, Lu and colleagues found a potentially druggable target that could keep the protein locked in the cell's cytoplasm.

MEK, ERK emerge as targets

The process begins when the epidermal growth factor connects to its receptor on the cell surface.

This leads to:

* Activation of the MEK protein, which in turn activates ERK.

* ERK sticking a phosphate group to a specific spot on PKM2.

* Phosphorylation priming PKM2 for a series of steps that culminate in its binding to the protein importin, which lives up to its name by taking PKM2 through the nuclear membrane.

Once in the nucleus, the team showed that PKM2 activates two genes crucial to aerobic glycolysis and another that splices PKM RNA to make even more PKM2.

An experiment applying several kinase-inhibiting drugs to human glioblastoma cell lines showed that only a MEK/ERK inhibitor prevented EGF-induced smuggling of PKM2 into the nucleus. ERK activation then is mandatory for PKM2 to get into the nucleus.

"MEK/ERK inhibitors have not been tried yet in glioblastoma multiforme," Lu said. Phosporylated PKM2 is a potential biomarker to identify patients who are candidates for MEK/ERK inhibitors once those drugs are developed.

MEK inhibitor blocks tumor growth

The researchers also found that the two glycolysis genes activated by PKM2, called GLUT1 and LDHA, are required for glucose consumption and conversion of pyruvate to lactate, crucial factors in the Warburg Effect. Depleting PKM2 in tumor cell lines reduced glucose consumption and lactate production.

In mice, depleting PKM2 blocked the growth of brain tumors. Re-expressing the wild type protein caused tumors to grow. However, re-expression of a PKM2 mutant protein that lost its ability to get into the nucleus failed to promote tumor formation. Experiments in human glioblastoma cell lines showed the same effect.

Injecting the MEK inhibitor selumetinib into tumors inhibited tumor growth, reduced ERK phosphorylation, PKM2 expression and lactate production in mice. In 48 human tumor samples, the team found that activity of EGFR, ERK1/2 and PKM2 were strongly correlated.

Cause of PKM2 overexpression

Lu and colleagues also published a paper in Molecular Cell that revealed a mechanism for overexpression of PKM2 in glioblastoma. They found that EGF receptor activation turns on NF-KB, which leads to a series of events culminating in PKM2 gene activation.

PKM2 levels were measured in tumor samples from 55 glioblastoma patients treated with standard of care surgery, radiation and chemotherapy. The 20 with low PKM2 expression had a median survival of 34.5 months, compared to 13.6 months for the 35 patients with high levels of PKM2.

Level of PKM2 expression in 27 low-grade astrocytomas was about half of the expression found in higher grade glioblastomas.

"In these two papers, we show how PKM2 is overexpressed in tumors, how it gets into the nucleus, that nuclear entry is essential to tumor development, and identified potential drugs and a biomarker that could usefully treat people," Lu said.

Co-authors of the Nature Cell Biology paper are first author Weiwei Yang, Ph.D., Yanhua Zheng, Ph.D., Yan Xia, Ph.D., and Haitao Ji, Ph.D., of MD Anderson's Department of Neuro-Oncology and Brain Tumor Center; Xiaomin Chen, Ph.D., of MD Anderson's Department of Biochemistry and Molecular Biology; Ken Aldape, M.D., MD Anderson's Department of Pathology; Fang Guo, Ph.D., Nanomedicine Center, Shanghai Research Institute, China Academy of Science; Costas Lyssiotis, Ph.D., and Lewis Cantley, Ph.D., Beth Israel Deaconess Medical Center, Harvard Medical School.

This research was funded by grants from the National Institutes of Health (numbers 2RO1CA109035, RO1GM068566 and RO1GM56302), MD Anderson's Cancer Center Support Grant (CA16672) from the National Cancer Institute; and a research grant from the Cancer Prevention and Research Institute of Texas.

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The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Weiwei Yang, Yanhua Zheng, Yan Xia, Haitao Ji, Xiaomin Chen, Fang Guo, Costas A. Lyssiotis, Kenneth Aldape, Lewis C. Cantley, Zhimin Lu. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology, 2012; DOI: 10.1038/ncb2629

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/_dUZzBAdjxE/121126164003.htm

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Monday, November 26, 2012

Mississippi Childhood Obesity Rate Slowly Improving Your Health ...

From The Sun Herald?..

The obesity rate for Mississippi?s children has stabilized, but the same cannot be said of adults. A recent study shows that by 2030, 67 percent of Mississippi?s adults are projected to be obese.

These projections released in September by Trust for America?s Health and the Robert Wood Johnson Foundation would indicate a significant increase from Mississippi?s current 35 percent obesity rate, expecting the state to hold its title as ?the fattest state in the nation for at least two more decades,? according to an article printed in a September issue of Sun Herald written by AP Medical Writer Mike Stobbe.

Recent data collected from Child and Youth Prevalence of Obesity Surveys, however, shows childhood obesity in Mississippi has remained level since 2005.

?We are making some progress. We haven?t taken a downturn, but we also haven?t got any better,? state health officer Mary Currier said. ?Don?t expect it to be a quick change.?

A 2011 CAYPOS study revealed the 43.9 percent rate in 2005 of obesity and overweight children grades kindergarten through 12 to have gone down to 40.9 percent. The decrease, however, is not considered ?statistically significant.?

On the other hand, the rate of obese and overweight white students decreased from 40.6 to 34.8 percent. In addition, the elementary student rate went down to 37.3 percent in 2011 from 43 percent in 2005.

The study, published in the Journal of the Mississippi State Medical Association, states the prevalence of combined obese and overweight public school students ?no longer appears to be increasing,? information they refer to as ?encouraging news for the state.?

The leveling off of these statistics may be the result of countless school programs and campaign efforts to encourage healthier, more active lifestyles in students.

One of these programs, Project Fit America, recently awarded exercise equipment to Gautier Middle School and also provided staff-led cardiovascular health and lifetime fitness education programs to the students.

?This program is one of many efforts they are involved in,? said Executive Director Sheila Grogan of Blue Cross & Blue Shield Mississippi Foundation, which oversees Project Fit and other programs throughout the state, ?The unique thing about our foundation is we only fund programs without measurable outcomes that can be identified such as a decrease in BMI over time or improvements in physical fitness tests.?

Currier said there are many things happening to help the health situation, but many things still to be done.

With the Healthy Schools Act enacted in 2007, many schools have stopped frying foods and incorporated healthier options in vending machines. Currier said there also has been an increase in farmers markets and having access to locally grown, unprocessed foods which avoid the excess fats, sugars and salts.

?The main thing is we have to change our eating habits,? Currier said. ?We find any occasion or event and celebrate it with food; We bring a ham, a cake. We need to change the culture.?

To read the full story?..Click here

Source: http://www.lensaunders.com/wp/?p=7469

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Sunday, November 25, 2012

Vivian Norris: A Buddhist Perspective on Nuclear Energy, Weapons and Taking Responsibility

While attending a weekend of meditation, prayer and the dedication of 108 statues of Amitabha, also known as the "Buddha of Buddhas," I had the chance to interview Sungjang Rinpoche. He is both a laughing spirit, yet beautifully focused young man who is recognized as the reincarnation, by the Dalai Lama, of the fourth Ngawang Drakpa, the disciple of Je Tsong Khapa, who founded the school of Dala?-lamas in the 15th century. Sungjang Rinpoche is living in exile at the Tatsang Ling monastery in France, and as more and more Tibetans flee the hardship and suffering in their native land, we are horrified to learn that the number of Tibetan Buddhist monks self-immolating has now reached at least 76 in the past few years. Petitions are circulating to help bring awareness to the horrific destruction of the environment, people and traditions of Tibet.

When I knew I would be interviewing Sungjang Rinpoche, I thought we would focus on Tibet, or Buddhism, but what we ended up talking about surprised me. When I asked him what he felt was the most important thing he could speak about to a wide audience, he replied, "We live in a dangerous time, of nuclear threats." He spoke of how these man-made threats, precisely because they were made by man, could also be stopped by man. And that we each had an important responsibility, not politicians, not governments, but each one of us, to take responsibility for our world. He spoke about Fukushima and how we do not really know how much radiation has already or will in the future rain down on us. Fukushima is still unstable yet we hear very little about it anymore. Sungjand Rinpoche said, "Fukushima releases a lot of radioactivity in the sky and it can fall on America, Alaska, China, Russia and Europe. We should end all nuclear energy because even that can be like a nuclear bomb. It will kill everybody. The main point is in society we have to change the dissatisfaction and selfishness to Love."

He spoke of the Cold War and how even though it is over, unstable nations with nuclear weapons threaten us. I was happily amazed at how he was completely focused on this issue of a nuclear threat which could destroy the planet and cause illnesses. I told him I had written a great deal about Fukushima and that I thought it was being forgotten. He repeated that we were destroying the future for our children, destroying the planet, and bringing about destruction which in Buddhist teachings is usually left to unkind, technologically advanced aliens travelling to Earth to bring about the Shambalic ending of this world.

This plain-speaking young man in his deep red and gold robes, praying with such intent for all of us, a living Buddha in his own right, expressed a deep compassion for the suffering of the entire planet and all of the living beings on it as he spoke of the nuclear threat. Interspersed with his usual child-like laughter, he would sway between a serious frowned brow and an open face smiling and sharing.

I asked him about the series of prayers we had dedicated to those who harm us, the humans who treat us cruelly and whose negative energy attempts to hurt us. We were taught that these people could be our greatest spiritual teachers and that we should in fact thank them. I asked him if the destruction and pollution of this planet could also have a lesson in it. He agreed and once again brought up the nuclear threats all around us. He spoke of the threat to all sentient beings, not just human beings. He spoke of how we need to no longer speak as countries as each country's interests destroys the others. He added, "Think globally. Act globally. We need to be careful not to hurt people. The Lord Buddha said do not destroy others' happiness for your own happiness."

"We are interdependent economically, environmentally, everything is connected. We are all human. We are all the same. We are all world citizens."

I wish to thank Celine Menguy for inviting myself and my daughter to participate during these amazing two days of dedication, initiation and prayer and Sofia Stril-Rever for all of her hard work and devoltion to Buddhism and hosting us at the monastery. My daughter and myself were extremely moved by the two days in the presence of someone who truly is focused on bringing more compassion to this world.

?

Follow Vivian Norris on Twitter: www.twitter.com/vivigive

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Source: http://www.huffingtonpost.com/vivian-norris-de-montaigu/a-buddhist-perspective_b_2189010.html

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The Journey Of the Fallen Prince

The Journey Of the Fallen Prince

The Kingdom has fallen after the royal family have been brutally murdered... The young prince is injured but is soon found...Become a part of his journey.

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.




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Hair Care Treatment At Home - Ayushveda

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Rating: 5.0/5 (1 vote cast)

Hair Care TreatmentBeautiful and healthy hair is very necessary to enrich the physical appearance of a person. Hence it is very necessary to maintain your hair with lot of care. The changing food patterns, weather conditions, level of pollution etc are the main factors that affect hair badly.

Especially the youth face lot of hair problems. Hence proper hair care treatment is very essential when your hair is affected badly or to take precautions for the same. Hair care treatment can be done by you with minimum cost. Some of the common hair problems may be split ends, dry hair, dandruff problem etc.

Below mentioned are a few hair care treatment that can be done with minimum efforts and cost. This has proved to be advantageous to people in various ways that have been affected by damaged and dull hair.

Hair Care Treatments

Mixture of Various Oils

Mix oils like coconut oil, olive oil, castor oil and gingili oil and glycerine in equal proportion. Apply this to the roots of your hair and massage well. This reduces split ends and brings good shine to your hair and ensures good hair growth.

Use of Soap Nuts

If you are allergic to the shampoos available in the market, the best option would be to use soap nuts. Soak it in water and create a fine lather. You can use this just like how you use shampoo and can use this every time you wash your hair.

Use of Henna

You can also make a good paste of henna leaves and keep it overnight. Apply this to your hair and wash till it dries completely. This will give natural colour to your hair and keeps your hair healthy.

Homemade Hair Care Treatment

You can also boil henna leaves in coconut oil and once it boils, discard the henna leaves. You can store it in a clean bottle with a closed lid and use whenever you want.

Also Read

Effective Hair Treatments At Home
Natural Ways To Treat Damaged Hair
Packs For Damaged Hair
Hail Loss Treatment

Use of Fenugreek

Apply fenugreek powder mixed with coconut oil on the hair scalp and gently massage. This is helpful in preventing hair loss. You can mix fenugreek powder with lime juice and apply on the scalp. This helps you reduce dandruff. A fine fenugreek paste has to be applied on your hair scalp and has to be washed after 2 hours. This would help you to reduce hair loss gradually.

Good and a Healthy Diet

The food you consume has to be very nutritious. Make sure to eat all type of food that would help you to grow good hair. Consumption of green tea is a good and an effective medicine for hair loss. It is also necessary to drink lot of water as it would help in hair growth. This has proved to be a healthy way to treat your hair.

All the tips mentioned above are very easy to follow and is known to be the right treatment for various hair problems. As this is natural and does not have any side effects, it is proved to be the best for people suffering from various hair problems. Make sure to follow these for strong, lustrous and problem free hair.

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Hair Care Treatment At Home, 5.0 out of 5 based on 1 rating

Source: http://www.ayushveda.com/mens-magazine/hair-care-treatment-at-home/

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Report: Impunity endangers Somalia's journalists

NAIROBI, Kenya (AP) ? Somalia's journalists are urging their new government and the international community to help end the impunity they say is contributing to making Somalia one of the world's most dangerous countries to practice journalism.

So far 18 Somali journalists have been killed this year and 44 since 2007.

The National Union of Somali Journalists on Friday said that impunity has become a fundamental problem in Somalia. Journalists in almost every region of the country commonly face harassment, blackmail, arbitrary police detention and, in addition, criminals are hired to suppress them, said the group in a report to mark the International Day to End Impunity, sponsored by the free expression group, IFEX.

"Despite this, the authorities provide no support to journalists, and the perpetrators operate with impunity," the report said. Journalism in Somalia has reached a state of emergency, said the report. None of these crimes are investigated properly, much less prosecuted, despite successive administrations, the report said.

No action has ever been taken following a case of violence against a Somali journalist, the report said.

Journalists are being targeted to silence them from speaking against corruption, violence and violations of human rights by radical Islamist groups, said Somali Journalist Mohamed Bashir Hashi.

"We are on the lookout behind our backs every minute because media is getting lots of enemies in Somalia," said Hashi, a reporter with the local Shabelle radio in Somalia.

Somalia's government should implement judicial reforms that will aid free and fair trials, as well as provide judicial protection for the media and ensure that police adhere to the law, according to the report titled "Impunity: War on Somali Journalists." The international community can assist Somalia's federal government to put in place effective and functional public law and order, the report said.

Somalia has made significant strides politically this year in trying to establish its first functional government to move the country away from its failed state status.

A new interim constitution has been passed, a new parliament was seated and a new president was voted in. Somali elders were tasked with naming the parliament since no election could be held, given the state of security around the country. Parliament in turn elected a new president who named a prime minister, who announced his cabinet earlier this month.

Although Somalia has had transitional administrations since 2004, it has not had a functioning central government since 1991, when warlords overthrew a longtime dictator and turned on each other, plunging the impoverished nation into chaos. The transitional governments lacked legitimacy and were accused of corruption.

The parliament last week voted to reduce the Cabinet to 10 members, in a sign Somalia's government may be willing to move away from its corrupt past.

African Union troops have helped to push Islamist extremists called al-Shabab out of all Somalia's major cities, giving the newly elected government a chance to rebuild the country.

The International Federation of Journalist says the al-Qaida-affiliated al-Shabaab has a bloody record of maiming and killing journalists who do not toe their line.

With Hizbul-Islam, another hardline insurgent group, they have in recent years ratcheted up pressure on radio stations, first and foremost to ascertain their authority on what goes on air and, most importantly, to impose Taliban-type commandments on un-Islamic music, ringtones, film and football, said Jim Boumelha, the IFJ president.

Boumelha said September was the bloodiest month as renewed killings of journalists may have been triggered by the recent change of government.

On September 20, suicide bombers blew themselves in a restaurant in Mogadishu killing three journalists and wounding five others. The following day another journalist, Hassan Yusuf Absuge, working for Radio Maanta, was shot dead near his station, Mogadishu. Al-Shabaab claimed that their supporters did it.

"With a new speaker of parliament, a new president and a new cabinet, the Somali journalists and their union expect a new beginning and a fresh commitment to protect journalists and tackle impunity as a priority and to promote the right to free expression," he said.

___

Associated Press writer Abdi Guled contributed to this report from Mogadishu, Somalia

___

http://daytoendimpunity.org

Source: http://news.yahoo.com/report-impunity-endangers-somalias-journalists-164456131.html

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Saturday, November 24, 2012

Mini Must-Have: Mason Disick?s Cool (and Cozy!) Hat

While visiting Paris with his parents Kourtney Kardashian and Scott Disick, Mason wore an adorable ensemble including Le Top's aviator cap.

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/61iIylK6af8/

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Video: This week on TODAY: Kesha, Twinkies and more

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Friday, November 23, 2012

New insights into virus proteome: Unknown proteins of the herpesvirus discovered

ScienceDaily (Nov. 23, 2012) ? The genome encodes the complete information needed by an organism, including that required for protein production. Viruses, which are up to a thousand times smaller than human cells, have considerably smaller genomes. Using a type of herpesvirus as a model system, the scientists of the Max Planck Institute (MPI) of Biochemistry in Martinsried near Munich and their collaboration partners at the University of California in San Francisco have shown that the genome of this virus contains much more information than previously assumed.

The researchers identified several hundred novel proteins, many of which were surprisingly small. The results of the study have now been published in Science.

More than 80 percent of the world's population is infected with the herpesvirus, which can cause severe diseases in newborns and in persons with weakened immune system. Researchers had already sequenced the herpesvirus genome 20 years ago, thinking they could then predict all proteins that the virus produces (virus proteome). Now scientists from the research department of Matthias Mann, director at the MPI of Biochemistry, and their American colleagues have analyzed the information content of the genome more precisely.

Small but highly complex

To carry out their study, the scientists infected cells with herpesvirus and observed which proteins the virus produced inside the cell over a period of 72 hours. In order for proteins to be produced at all, the cell machinery must first make copies of the genetic material as intermediate products (RNA). While investigating the intermediate products of the herpesvirus, the American collaborators discovered many novel RNA molecules which were in large part surprisingly short.

They also found that the organization of information required for protein production in the virus genome was far more complex than previously assumed. Annette Michalski, a scientist in the Department of Proteomics and Signal Transduction at the MPI of Biochemistry, was subsequently able to confirm directly the predicted viral proteins in the infected cell using mass spectrometry. This method enables an overview of the complete proteome of the virus-infected cell.

The results of the American and German researchers provide detailed insight into the complex mechanisms used by the virus. "We showed that it's not enough merely to know the virus genome to understand the biology of the herpesvirus," Annette Michalski said. "What is important is to look at the products actually produced from the genome." Even human genes may be much more complex than the genome sequence itself indicates, commented the researchers. Matthias Mann and his colleagues plan to investigate this question further in the coming years.

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The above story is reprinted from materials provided by Max Planck Institute of Biochemistry.

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Journal Reference:

  1. N. Stern-Ginossar, B. Weisburd, A. Michalski, V. T. K. Le, M. Y. Hein, S.-X. Huang, M. Ma, B. Shen, S.-B. Qian, H. Hengel, M. Mann, N. T. Ingolia, J. S. Weissman. Decoding Human Cytomegalovirus. Science, 2012; 338 (6110): 1088 DOI: 10.1126/science.1227919

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/aXKHk3WyAFY/121123092132.htm

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Could A Twinkie-Stuffed Turkey Replace the Turducken?

When it comes to preparing a Thanksgiving turkey, the focus these days seems to be on what ridiculous things you can stuff inside. And the Turducken, which sees the bird stuffed with a duck-stuffed chicken, might have met its match with the Turtwinkie. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/0ZuywOep7mY/could-a-twinkie-stuffed-turkey-replace-the-turducken

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Thursday, November 22, 2012

Beneficial microbes are 'selected and nurtured' in the human gut

Thursday, November 22, 2012

Animals, including humans, actively select the gut microbes that are the best partners and nurture them with nutritious secretions, suggests a new study led by Oxford University, and published November 20 in the open-access journal PLOS Biology.

The Oxford team created an evolutionary computer model of interactions between gut microbes and the lining (the host epithelial cell layer) of the animal gut. The model shows that beneficial microbes that are slow-growing are rapidly lost, and need to be helped by host secretions, such as specific nutrients, that favour the beneficial microbes over harmful ones.

The work also shows that the cost of such selectivity is low: the host only needs to use a very small amount of secretions to retain beneficial microbes that would otherwise have been lost.

"The cells of our bodies are greatly outnumbered by the microbes that live on us and, in particular, in our gut," said Professor Kevin Foster of Oxford University's Department of Zoology, an author of the new paper. "We know that many gut microbes are highly beneficial to us, protecting us from pathogens and helping us with digestion, but quite how such a beneficial mutual relationship evolved, and how it is maintained, has been something of a mystery."

"This research highlights the importance of growth-promoting substances in our ability to control the microbes that live inside us. It shows that nutrients are more powerful when released by the host epithelial cell layer than when coming from the food in the gut, and suggests that controlling our microbes is easier than was previously thought."

Jonas Schulter, also of Oxford University's Department of Zoology and first author of the paper, said: "The inside of our gut is rather like a war zone, with all kinds of microbes battling it out for survival and fighting over territory. Our study shows that hosts only have to secrete a small quantity of substances that slightly favour beneficial microbes to tip the balance of this conflict: it means that favoured microbial species that would otherwise be lost don't just survive on the epithelial surface but expand, pushing any other strains out."

The team's simulations show that cells affected by host epithelial selection are least likely to be lost, and instead persist longest, causing 'selectivity amplification', whereby relatively tiny changes instituted by the host (in this case a very small amount of secretions of certain compounds) can be amplified to produce a large-scale effect.

The study may have wider implications than the human gut: selectivity amplification may occur in a range of other interactions between hosts and microbes, including the microbes that grow on the surface of corals and the roots of plants.

###

Schluter J, Foster KR (2012) The Evolution of Mutualism in Gut Microbiota Via Host Epithelial Selection. PLoS Biol 10(11): e1001424. doi:10.1371/journal.pbio.1001424

Public Library of Science: http://www.plos.org

Thanks to Public Library of Science for this article.

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Source: http://www.labspaces.net/125409/Beneficial_microbes_are__selected_and_nurtured__in_the_human_gut

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